The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown. During the initiation phase, small amounts of FXa is generated by Tissue Factor exposure at the site of injury. TF complexes with FVIIa generating FXa which itself complexes with FVa to generate thrombin (extrinsic pathway). TF-FVIIa also activates FIX along with FXIIa (intrinsic pathway). Thrombin, then primes additional multicomponent complexes on platelets (and endothelial cells, not shown) (amplification phase). Once activated the multicomponent complexes are optimally positioned to generate large amounts of thrombin (propagation phase).

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