Paget's Disease of Bone



 • Characterized by an ↑ rate of bone turnover with both excessive resorption and formation of bone, leading to a "mosaic" lamellar bone pattern appearance on x-ray.

 • Caused by (suspected) the effects of a latent viral infection in genetically susceptible individuals.

 • Associated with 1° hyperparathyroidism and ↑ risk for osteosarcoma.

 • The disease can affect one (monostotic) or more (polystotic) bones, with the skull, vertebral bodies, pelvis, and long bones most commonly affected.



By @medperspective 



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