Night Sweats - Differential Diagnosis Framework



Night sweats are a nonspecific symptom that patients commonly experience and report in the primary care setting. Most do not have a serious underlying disorder.



MALIGNANCY

• Lymphoma

• Leukemia

• Other neoplasm



INFECTIONS

• Human immunodeficiency virus

• Tuberculosis

• Mycobacterium avium complex

• Infectious mononucleosis

• Fungal infections (histoplasmosis, coccidioidomycosis)

• Lung abscess

• Endocarditis

• Other infections



ENDOCRINE

• Ovarian failure

• Hyperthyroidism

• Diabetes mellitus (nocturnal hypoglycemia)

• Endocrine tumors (pheochromocytoma, carcinoid tumor)

• Orchiectomy



DRUGS

• Antipyretics (salicylates, acetaminophen)

• Antihypertensives

• Phenothiazines

• Substances of abuse: alcohol, heroin



RHEUMATOLOGIC

• Takayasu's arteritis

• Temporal arteritis



OTHER

• Obstructive sleep apnea

• Gastroesophageal reflux disease

• Chronic fatigue syndrome

• Granulomatous disease

• Chronic eosinophilic pneumonia

• Lymph node hyperplasia

• Diabetes insipidus

• Prinzmetal's angina

• Anxiety

• Pregnancy

• Autonomic over-activity

• Obesity



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