Insomnia Medications



Natural Products:

 • Melatonin

 • Valerian



Hypnotics and Antidepressants

Non-BZDs: increase GABA

 • Eszopiclone

 • Zolpidem

Orexin-receptor antagonist: promotes wakefulness

 • Suvorexant

Melatonin Receptor Agonists: induces sleepiness & regulates circadian rhythm

 • Ramelteon

 • Tasimelteon

Antidepressants: Block H1 receptor & 5-HT effects

 • Doxepin

 • Trazodone



BZDs & Antihistamines

BZDs: Increase GABA

 • Lorazepam

 • Temazepam

Antihistamines: block H1 blockers

 • Diphenhydramine

 • Doxylamine



By Kyle Fischer, PharmD @Kfischer_10



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