Several artifacts can cause significant and potentially ...
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Description

Several artifacts can cause significant and potentially misleading alterations to measured RBC parameters: 

1. Old samples cause RBCs to swell, thus increasing PCV and MCV and decreasing MCHC; 

2. Lipemia causes a falsely high Hgb reading, and hence a falsely high MCHC; 

3. Hemolysis causes PCV to decrease while Hgb remains unchanged, again leading to a falsely high MCHC; 

4. Underfilling of the tube causes RBCs to shrink, causing PCV and MCV to decrease and MCHC to increase; 

5. Autoagglutination causes a falsely low RBC count, and hence a falsely high MCV.



Satyendra Dhar MD @DharSaty

#Poikilocytosis #CabotRings #Acanthocytes #TearCells #Dacrocytes, #Teardrops #TargetCells #Codocytes #Stomatocytes #Spherocytes #SickleCells #Drepanocytes #Schistocytes #Pyknocytes #Elliptocytes #Ovalocytes #Echinocytes #BurrCells #Bite #Keratocyte #Blister #HelmetCells
Contributed by

Satyendra Dhar, MD
@DharSaty
Hospital Medicine
Assistant Clinical Professor

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