Hypokalemia - Differential Diagnosis Algorithm



Transcellular Shift:

 • Alkalosis

 • ↑ beta-2 adrenergic simulation 

 • Erythropoiesis (B12 injections in pernicious anemia)

 • G-CSF

 • Hypokalemic periodic paralysis

 • Refeeding syndrome

 • Thyrotoxicosis

Medications

Renal Losses

Non-renal losses: 

 • GI losses (NG suction, diarrhea, vomiting)

 • Low K intake (anorexia, dementia, starvation, TPN)

 • Transcellular shifts

 • Discontinued diuretic



Matthew Ho, MD PhD @MatthewHoMD



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