Cryoglobulinemia Classification Types



Type 1: Monoclonal IgM (rarely IgG/lgA)

 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity (may be seen when IgM > 4 g/dL)



Mixed:

 • Type 2: Monoclonal IgM (RF) and polyclonal IgG

 • Type 3 (25%): Polyclonal IgM and polyclonal IgG

 • Type 2-3: Oligoclonal IgM and polyclonal IgG

 • Meltzer's triad: purpura, arthralgia, weakness

 • Liver, kidney (MPGN), peripheral neuopathy, pulmonary (dyspnea, cough, pleurisy)



Matthew Ho, MD PhD @MatthewHoMD



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