Iron Deficiency in Congestive Heart Failure (CHF)



Iron deficiency (ID) in heart failure is a common comorbidity affecting up to 50% of patients, leading to:

 ↑ HF Hospitalization

 ↓ Quality of life and hospitalizations survival

 ↓ Exercise capacity



Diagnosis:

 • Ferritin < 100 ng/mL OR Ferritin 100 - 299 ng/mL + TSAT < 20%



Risk Factors:

 • Female sex

 • More advanced stages of HF

 • Higher NT-proBNP and CRP



Ganzoni Equation:

Iron deficit (mg) = [body weight (kg) x (target Hgb — actual Hgb) x 2.4 + depot iron]



Treatment Options (IV Iron Preferred)

 • Ferric carboxymaltose - 750 mg

 • Ferric gluconate - 125-150 mg

 • Ferumoxytol - 510 mg

 • Iron dextran - 100 mg

 • Iron sucrose - 100-200 mg



By Kyle Fischer, PharmD @Kfischer_10



#Iron #Deficiency #Heart #Failure #CHF #pharmacology #pathophysiology #cardiology