Hemolytic Anemias - Differential Diagnosis Algorithm



Signs of anemia and hemolysis:

 • ↓ Haptoglobin

 • ↑ LDH

 • ↑ Indirect / unconjugated bilirubin

 • ↑ Reticulocytes

 • Abnormal peripheral smear



Immune-mediated Hemolysis:

 • Autoimmune Hemolytic Anemias (AIHAs)

 • Alloimmune Hemolytic Anemias (AHAs)

Nonimmune-mediated Hemolysis:

 • Extrinsic RBC Defects: Hypersplenism, Infection, Toxic, Mechanical, Macroangiopathic, Microangiopathic

 • Intrinsic RBC Defects: Membrane defects, Enzyme deficiencies, Hemoglobinopathies



Matthew Ho, MD PhD @MatthewHoMD



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