Iron Deficiency Anemia - Differential Diagnosis Algorithm



Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR



 • Blood loss: GI bleed, GU bleed, Gyn bleed, Epistaxis, Surgery, Hemodialysis

 • Iron loss: Intravascular (not extravascular) hemolysis, Intensive athletic training, Pulmonary hemosiderosis

 • Malabsorption:

    - Achlorhydria: PPI/H2 blocker, H. pylori, Atrophic gastritis, Gastrectomy, WHDA syndrome, Vagotomy

    - Structural: Celiac disease, Tropical sprue, IBD, Bypass surgery, Bacterial overgrowth, Hookworm, whipworm

    - Other nutrients: Zinc excess or deficiency, Copper deficiency, Lead poisoning

 • Inadequate intake: Anorexia, Pregnancy, Lactation, Low iron diet, Alcoholism, Tea-toast, TPN



Matthew Ho, MD PhD @MatthewHoMD



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