Guideline-Directed Medical Therapy (GDMT) in HFrEF and CKD



 • Class I pillars of HFrEF GDMT across the span of kidney disease: ACEI, ARB, ARNI, BBs, Loop diuretics, MRA, SGLT2i, Nitrate, Vasodilator

 • Class II "additional therapies" for HFrEF GDMT after core GDMT has been optimized: IKi, sGC stimulator, Chronotropes

 • Medications that are not strictly defined as part of HFrEF GDMT but are commonly used in HFrEF: Statins, Thiazides



By Jiun-Ruey Hu, MD & Jiawei Tan, MD



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