Salicylate Poisoning - Toxicology



Acute toxicity = vomiting, tachypnea, tinnitus, diaphoresis, and lethargy. This may progress to seizures, hypoglycemia, hyperthermia, coma, and pulmonary edema. Blood gas usually reveals a mixed respiratory alkalosis and metabolic acidosis.



Chronic toxicity = delirium, dehydration, and tachypnea. Cerebral and pulmonary edema occurs more frequently than with acute toxicity. Severe poisoning occurs at lower salicylate concentrations, and the mortality rate is higher than in acute poisoning.      



Decontamination

Urine Alkalinization



By Dr. Kathryn Watson @Kat_Watson



#Salicylate #Toxicity #Toxicology #Pharmacology #Diagnosis #Management #Aspirin