Patterns of Liver Injury

Transaminase Levels:

  > 50x normal - Ischemic Hepatitis

  > 20x normal - Acute Viral Hepatitis, Toxic Hepatitis

  10-20x normal - Infection (EBV/CMV), Alcoholic cirrhosis, Portal Vein Thrombosis

  5-10x normal - Chronic hepatitis, Skeletal muscle

  2-5x normal - Hemolysis, NASH, Genetic / Metabolic.

By AST:ALT Ratio:

   AST:ALT = 1 - Ischemia, CHF

   AST:ALT > 2.5 - Alcoholic Hepatitis

   AST:ALT < 1 - Viral Hepatitis, Ischemic Necrosis, Toxins



By Dr. Khushboo Gala @LouLectures



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