High-Res Chest CT Patterns - Differential Diagnosis Framework

Reticular:

 • Septal Thickening: Lymphangitic Carcinoma, Interstitial Edema, Alveolar Proteinosis, Lymphoma, Sarcoidosis, Silicosis

 • Honeycombing - See Low Attenuation

Nodular:

 • Random: Metastases, Miliary Infection (TB, Fungal)

 • Perilymphatic: Sarcoidosis, Silicosis, Lymphangitic Carcinoma, Coal Pneumoconiosis

 • Centrilobular: Hypersensitivity Pneumonitis, Respiratory Bronchiolitis, Bronchopneumonia

High Attenuation:

 • Acute Ground Glass: Edema, Hemorrhage, Pneumonia, Acute Hypersensitivity, Acute Eos PNA

 • Chronic Ground Glass: Hypersensitivity Pneumonia, COP, Chronic Eos PNA, Fibrosis, BAC

 • Crazy Paving: Alveolar Proteinosis, Sarcoidosis, NSIP, COP, Infection, Neoplasm (BAC), Hemorrhage, Edema

 • Consolidation: Pus, Blood, Water, Tumor

Low Attenuation:

 • Emphysema: Smoking, Alpha-1-Antitripsyn Def

 • Cysts: Congenital, Langerhans Histiocytosis, Lymphocytic Int PNA, Lymphangioleiomyomatosis

 • Honeycombing: Idiopathic Pulmonary Fibrosis, RA, Scleroderma, End-Stage Hypersensitivity, End-Stage Sarcoidosis

 • Bronchiectasis: Prior Infection, Aspiration, Cystic Fibrosis, ABPA, Immune Deficiency



Sophia Hayes MD @Sophia_Hayes_MD



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