Chemotherapy Toxicity Bear Mnemonic - Cumulatively Toxic Drugs and their Rescues
 • Asparagine: neurotoxicity
 • Cisplatin: ototoxic/nephrotoxic; Tx: Amifostine
 • Vincristine/Vinblastine: "Christ my nerves, Blast my bones" - Vincristine = peripheral neuropathy, Vinblastine = myelosuppression
 • Bleomycin: pulmonary fibrosis
 • Doxorubicin: cardiotoxic; Tx; Dexrozoxane (for cardiotoxicity), Dimethyl-sulphoxide (for ROS ulcers)
 • Cyclophosphamide: Acrolein = nephro/bladder toxic (Tx: Mesna); also SIADH effects (Tx: Demeclocycline)
 • Methotrexate: nephrotoxic (Tx: Leucovorin), myelosuppression (Tx: Filgrastim)

Salim R. Rezaie, MD @srrezaie

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