Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison



Hodgkin's Lymphoma:

 • Epidemiology: young adults 20-30, older 50-70

 • Malignant lymphoma that is typically of B-cell origin

 • Etiology: Immunosuppression (e.g., HIV), EBV infection, Autoimmune diseases

 • Clinical features:

   - Adenopathy (painless)-localized above the diaphragm,

   - Contiguous spread

   - Lymph nodes in upper portion of the body (the neck, underarms, or chest).

   - B symptoms

   - Pel-Ebstein fever

   - Alcohol-induced pain: Pain in involved lymph nodes

   - Pruritus: (focal or generalized)

 • Usually no hepatosplenomegaly (Rare but might occur if the spleen or liver are involved)

 • No leukemic phase

 • Reed Sternberg cell

 • Prognosis: Good

 • ABVD , BEACOPP



Non-Hodgkin's Lymphoma:

 • Epidemiology: Increases with age (peak > 50 years)

 • Etiology:

   - Infections (HIV, EN, HTLV-1, HCV, H. Pylori)

   - Autoimmune diseases (e.g., Hashimoto thyroiditis, rheumatic disease)

   - Chromosomal translocation

 • Types: Classification based on:

   - Cell type (B cell, T cells, natural killer (NK) cells)

   - Location (nodal or extranodal)

   - Tumor grade

 • Adenopathy + Extranodal (Multiple lymph node groups)

   - Lymph nodes throughout the body, but can also arise in normal organs

   - Noncontiguous spread

 • Clinical features:

   - Nodal disease: B symptoms, lymphadenopathy, mass, Hepatosplenomegaly, cytopenias(bleeding)

   - Extranodal disease: GI, neuro, cutaneous involvement



Differential Diagnosis of B-Symptoms

 • Non-Hodgkin, Hodgkin Lymphomas

 • Other hematologic Malignancies (eg CML, ALL)

 • Solid Tumors

 • Tuberculosis

 • HIV



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