Causes of Angioedema: Differential Diagnosis Framework
Mast-cell mediated:
 • IgE dependent allergic reactions: Food, Drugs, Latex, Stings
 • Direct mast cell release: Opiates, Radiocontrast
 • Changes in arachidonic acid metabolism within mast cells: NSAlDs, Aspirin
Bradykinin mediated:
 • ACEi
 • Hereditary C1 esterase inhibitor deficiency (hereditary angioedema)
 • Acquired C1 esterase inhibitor deficiency
 • Fibrinolytics
Unknown Mechanisms: 
 • Idiopathic
 • Infections
 • CCV

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