Basophilia - Differential Diagnosis Framework



Basophils < 1% of the total white blood cell count

Basophils function similarly to mast cells- contain histamine in their granules which are released during an allergic reaction or asthma attack



Is It A Real Basophilia?

 • Pseudobasophilia possible.

 • Statistical error/delay in processing



Myeloproliferative Disorders:

 • Chronic myeloid leukemia (CML)

	- associated with the BCR-ABL1 fusion gene - reciprocal t(9;22) translocation

 • Acute myeloid leukemia

	- Basophils + circulating blasts

 • Polycythemia Vera

 • Essential thrombocythemia

 • Acute basophilic leukemia



Hypersensitivity Or Inflammatory Reactions:

 • Ulcerative Colitis and Crohn’s Disease

 • Asthma



Hypothyroidism (Myxedema)



Diabetes/DKA



Infections:

 • helminth infections

 • Tuberculosis

 • Influenza

 • Chickenpox



Other Causes:

 • Iron deficiency

 • Irradiation

 • Cirrhosis

 • Estrogen therapy



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