Vasculitis Involving the Skin - Differential Diagnosis Framework



Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis

Secondary: CTD: SLE, RA related vasculitis, infections, drug eruptions, paraneoplastic



Vasculitis Skin Findings:

 • Small Vessel: Petechiae, Palpable purpura, Hemorrhagic bullae, Ulceration, Urticaria

 • Medium Vessel: Subcutaneous nodules, Deep ulcers, Livedo reticularis, Livedo racemosa, Digital ulceration



Small Vessel Vasculitis:

 • Immune Complex Vasculitis:

	- Ig A (HSP)

	- Anti-C1q (Urticarial/LCV)

	- Cryoglobulinemic Vasculitis

 • ANCA Associated:

	- Microscopic polyangiitis

	- EGPA

	- GPA



Cutaneous Single Organ Vasculitis:

 • Leukocytoclastic vasculitis with IgG/IgM deposits

 • Nodular cutaneous vasculitis

 • Erythema elevatum diutinum



Medium Vessel Vasculitis:

 • Cutaneous polyarteritis nodosa

 • Polyarteritis nodosa



Large Vessel Vasculitis:

 • Temporal arteritis

 • Takayasu's arteritis



Variable Vessel Vasculitis:

 • Behcet Disease

 • Cogan syndrome



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