Legionnaires' Disease
Clinical features:
 • Gl- nausea, vomiting, diarrhea
 • Hyponatremia
 • Elevated transaminases
 • CRP >100
 • Failure to respond to B-Lactams
Treatment:
 • Levofloxacin
 • Azithromycin
 • Alternatives- Other FQ macrolides or tetracyclines
Duration:
 • Minimum 5 days (mild) 
 • At least 7-10 days- severe or comorbidities
 • Immunocompromised- 14 days minimum
Other Legionella Infections:
  1. Pontiac fever
  2. Extra-pulmonary: cellulitis, septic arthritis, OM, myocarditis, pericarditis, meningitis, pyelonephritis (immunocompromised patients)

Sinai Hospital of Baltimore IM Residency @SinaiBmoreIMRes

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