Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine, etc)
 - Viral: HIV, HCV, EBV, CMV
 - Bacterial: Sepsis
 - Parasitic: Malaria, babesia
 - Nutritional: B12, copper, folate def
 - Bone marrow infiltration: malignancy, infection (TB), MDS
 - Alcohol
Consumption:
 - Microangiopathy: DIC, TTP, HUS
 - Antibody-mediated: ITP, HITT
 - Autoimmune: SLE, RA, antiphospholipid syndrome
 - Pregnancy: HELLP
 - Mechanical: valve replacement, endocarditis
Splenic sequestration:
 - Cirrhosis with portal HTN
 - Anything causing splenomegaly

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