Dexmedetomidine - Anesthesia Pharmacology
Trade Name: Dexmedetomidine
Brand Name(s): Precedex
Drug Type: Sedation
Time of Onset: 30 minutes
Duration of Action: N/A
Mechanism of Action: Highly selective agonist of CNS alpha2-receptors
Cessation of Action: Rapid hepatic metabolism
Systems:
  - Central Nervous System - hypnotic agent due to stimulation of alpha2-receptors in the ceruleus, reducing its activity; sedative effect achieved by activation of endogenous sleep pathways; decreases CBF without significantly affecting CMRO2 and ICP
  - Cardiovascular - reduces heart rate and systemic vascular resistance, thus lowering systemic arterial blood pressure
  - Respiratory - moderately reduces tidal volume and to a lesser extent, respiratory rate

David Convissar, MD @countbackwardsfrom10

#Dexmedetomidine #Precedex #Anesthesia #Pharmacology