Ketamine - Anesthesia Pharmacology
Trade Name: Ketamine
Brand Name(s): Ketalar
Drug Type: Induction
Time of Onset: Rapid
Duration of Action: 5 - 10 minutes
Mechanism of Action: Inhibition of the NMDA receptor complex
Cessation of Action: Hepatic metabolism and redistribution to inactive tissue sites
Systems:
  - Central Nervous System - Increases CBF and CMRO2
  - Cardiovascular - large but transient increases in systemic arterial blood pressure, along with cardiac output and heart rate via inherent catecholamines. Otherwise, direct myocardia depressant.
  - Respiratory - relaxes bronchial smooth muscles but does not induce significant respiratory depression

David Convissar, MD @countbackwardsfrom10

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