Causes of Wide Pulse Pressure - Differential Diagnosis
Physiologic:
 • Advanced age-arteriosclerosis (less compliant arteries)
 • Well conditioned athletes
Pathologic:
 • Valvular disorders: 
    - aortic regurgitation
    - aortic sclerosis (both heart valve conditions)
 • Severe intravascular hypovolemia
    - Severe iron deficiency anemia (reduced blood viscosity)
    - anemia
    - Volume depletion
 • Hyperdynamic circulation/High output heart failure:
    - Hyperthyroidism/Thyrotoxicosis
    - Wet Beriberi
    - Cirrhosis
    - Erythroderma
    - Myeloproliferative disorders
    - Chronic pulmonary diseases
 • Arteriovenous fistula - Such as patent ductus arteriosus or peripheral arteriovenous malformations
 • Sympathetic overdrive
 • Elevated Intracranial Pressure
 • Vasoplegia
 • Sepsis

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