Causes of Constipation - Differential Diagnosis Framework
 • Motility: Diet, IBS-C, Colonic inertia, Pelvic floor disorders, Hirschsprung's
 • Neurogenic: Stroke, Multiple sclerosis, Parkinson's disease, Spinal cord injury, Neuropathy / myopathy
 • Mechanical: Stricture, Tumour, Prolapse / rectocele, Diverticular disease, Extrinsic compression
 • Drugs: Opioids, TCAs / mood stabilizers, Diuretics, Iron, Calcium supplements, etc
 • Metabolic: Diabetes, ↑Ca2, ↓K, Hypothyroidism, Hyperparathyroidism, Chronic kidney failure
 • Others: Scleroderma, Coeliac disease, Anal pain (e.g. fissure), Chronic laxative use, Psychological

Dr. Keith Siau @drkeithsiau

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