Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm
INDICATIONS FOR TESTING:
 • Vascular thrombosis
    - 1 or more clinical episodes of arterial, venous, or small-vessel thrombosis
 • Unexplained pregnancy loss defined as:
    - 1 or more unexplained deaths of a morphologically normal fetus beyond the 10th week of gestation
    - 1 or more premature births of a morphologically normal neonate before the 34th week of gestation due to eclampsia, preeclampsia, or placental insufficiency
    - 3 or more unexplained, consecutive, spontaneous abortions before the 10th week of gestation, and with maternal anatomic or hormonal abnormalities and paternal and maternal chromosomal causes excluded
Testing:
 • Lupus Anticoagulant Reflexive Panel
 • Cardiolipin Antibodies, IgG and IgM
 • Beta-2 Glycoprotein 1 Antibodies, IgG and IgM
 • Phosphatidylserine and Prothrombin Antibodies, IgG and IgMa
 • Phosphatidylserine Antibodies, IgG and IgMa
 • Prothrombin Antibody, IgGa
 • Cardiolipin Antibody, IgA
 • Beta-2 Glycoprotein 1 Antibody, IgA

ARUPConsult @ARUPLabs

#APLS #Antiphospholipid #Syndrome #Hypercoagulable #Workup #Algorithm #diagnosis #hematology