NSAID Selectivity Spectrum
COX-2 Selective NSAID - Celecoxib
 • Increased risk for CV events
 • Decreased risk for Gl side effects
Semiselective NSAIDs - Meloxicam, diclofenac, etodolac, indomethacin, piroxicam, nabumetone, sulindac
 • Increased affinity for COX-2 but still retain activity COX-1
 • Use with caution in patients at increased CV risk
Nonselective NSAIDs - Ibuprofen, naproxen
 • Decreased risk for CV events
 • Increased risk for Gl side effects
Irreversible Nonselective NSAID - Aspirin
 • Cardioprotective at low doses
 • Increased risk for GI side effects

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