Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary hypertension, Digital ulcers, Primary Biliary Cirrhosis
Anti-RNA polymerase III: Diffuse, Renal crisis, Rapid progressive skin fibrosis
Anti-PM-Sc1: Overlap myositis, Young age of onset
Anti-U3RNP (fibrillarin): African Americans and males, Overlap

BCM IM Residency @BCM_InternalMed

#Systemic #Sclerosis #Autoantibodies #diagnosis #rheumatology