Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from low platelets
 • Symptomatic anemia
Diagnosis:
 • Pancytopenia with hypocellular bone marrow biopsy without evidence of infiltration or megaloblastic anemia
Treatment:
 • Consider stem cell transplant
 • If no transplant, immunosuppressive therapy with eltrombopag, cyclosporine A, ATG (antithymocyte globulin), and prednisone
 • Supportive care (transfusions, antibiotics if neutropenic fever)
Complications:
 • Can progress to MDS or acute leukemia
 • Associated PNH

SCVMC Internal Medicine @SCVMCMed

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