Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm
ACTH-Dependent (Secondary):
 • Pituitary Dysfunction
 • Hypothalamic Dysfunction
ACTH-Independent (Primary):
 • Autoimmune: Isolated Adrenalitis, Polyglandular Autoimmune Syndrome
 • Infectious: TB, Disseminated Fungal, HIV/AIDS
 • Hemorrhagic: Coagulopathy, Thrombophilia (adrenal vein thrombosis), DIC, Waterhause Friedrichsen (Meningococcemia, Staph Aureus, Strep, Rickettsia), Trauma
 • Infiltrative: Malignancy, Granulomatous Disease, Amyloidsis, Hemochromatosis
 • Other: Surgery, Radiation, Medication

SCVMC Internal Medicine @SCVMCMed

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