Hydroxyurea - Pathophysiology and Benefits in Sickle Cell Disease • Decreases number of pain crises ( 4.5 vs. 2.4) • Decreases hospitalizations (2.4 vs. 1) • Fewer ACS ( 35% vs. 24%) • Fewer transfusions Possible end organ benefit and decreased mortality #Hydroxyurea #Benefits #SickleCell #pathophysiology #pharmacology
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