Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis (reduces complement activation → decreasing swelling in w/ hereditary angioedema)
 • Metabolism: Unknown, small amount of hepatic metabolism
 • Time to Onset: 5 - 15 minutes
 • Duration of Action: ~ 2-3 hours
 • Method of Excretion: Urine
Common Uses: Trauma, Epistaxis, Post-partum, ICH/TBI, Hemoptysis, GI Bleeding
Side Effects: Hypotension with rapid injection; Nausea, vomiting, diarrhea & abdominal pain; Dizziness, headache & fatigue; Increases risk of seizures; Hypersensitivity & anaphylaxis; Potentially increases venous & arterial thrombotic events; Impaired color vision & visual disturbances

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