Clinical Manifestations of Serotonin Syndrome
 • Ophthalmologic: Mydriasis, Ocular clonus (slow horizontal movements)
 • Gastrointestinal: Diarrhea, increased bowel sounds, RUQ pain
 • Dermatologic: Diaphresis, flushing
 • CNS: Agitation, Delirium, Rigidity, Hyperreflexia
 • Cardiovascular and vital sign abnormalities: Tachycardia, Fever, Hypertension, Late stages (shock)
Spectrum of Clinical Manifestations (Mild → Life-Threatening): Akathisia, Altered Mental Status (agitated), Tremor, Clonus (sustained), Clonus (inducible), Muscular Hypertonicity, Hyperthermia

UCSD Internal Medicine @ucsdim

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