Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 - Maternal hypertension and/or drug treatment
 - Maternal antibody production
 - Constitutional disorders, eg, cyclic neutropenia, Kostmann syndrome, Chediak-Higashi syndrome
Infant/child:
 - Infection-common
 - Autoimmune neutropenia
 - Neoplasms replacing the BM
 - Idiosyncratic drug reactions
 - Secondary autoimmune neutropenia in collagen vascular disorders
 - Immunodeficiency disorders
 - Myeloablative therapies
 - Constitutional neutropenia disorders-rare
 - Megaloblastic anemia-rare
 - Copper deficiency-rare
Adult:
 - Idiosyncratic drug reactions-most common cause in ambulatory patients
 - Infections-common
 - Neoplasms replacing the BM-common
 - Myeloablative therapies-common
 - Secondary autoimmune neutropenia in collagen vascular disorders
 - Autoimmune disorders including white blood cell aplasia

DOI: 10.1111/ijlh.13210

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