Longterm Venous Thromboembolism Treatment Algorithm
Treat for 3 months and reassess
 • Isolated distal DVT (without cancer) - Stop at 3 Months
 • Transient risk factor - Stop at 3 Months
 • Cancer - Indefinite therapy or until cancer inactive
 • Unprovoked proximal DVT or PE
    - High Bleeding Risk OR Prefers to stop even if D-dimer or APA was positive - Stop at 3 Months
    - Not High Bleeding Risk AND Prefers to stay on even if D-dimer was negative - Indefinite therapy
    - Second VTE - Indefinite therapy
    - Others - Stop and measure D-dimer and APA after 1 month
       • Negative D-dimer and APA - Stay off therapy (Stop at 3 Months)
       • Positive D-dimer or APA - Restart therapy (Indefinite therapy)

https://doi.org/10.1182/blood.2019002364

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