Algorithm for Metformin Prescribing and Dosing in CKD
Dose Initiation - Immediate release:
 • Initial 500 mg or 850 mg once daily
 • Titrate upwards by mg/d or 850 mg/d every 7 days until maximum dose
Dose Initiation - Extended release:
 • If Gl side effects from release
 • Initial 500 mg daily
 • Titrate upwards by 500 mg/d every 7 days until maximum dose

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