Causes of Peripheral Edema - Differential Diagnosis

Increased Hydrostatic Pressure

 • Volume Expansion: Kidney failure, Pregnancy, Medication side effect (e.g. prednisone, NSAIDs), Acute salt load, Heart failure

 • Venous Obstruction / Insufficiency: Heart failure, Pulmonary hypertension, Cirrhosis, Deep vein thrombosis, Chronic venous stasis

 • Arteriolar vasodilation: Dihydropyridine Ca2+ channel blockers

Decreased Oncotic Pressure (Hypoalbuminemia) Malnutrition, Cirrhosis, Nephrotic syndrome

Increased Capillary Permeability: Sepsis, Cellulitis

Lymphatic Obstruction (Lymphedema):

 • Malignancy: Lymph node dissection, Infiltration of lymphatics, Extrinsic compression of lymphatics

 • Filariasis (e.g. Wuchereria bancrofti, Brugia malayi)

Miscellaneous: Hypothyroidism



- Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedicalLectures/



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