Causes of Polyuria - Differential Diagnosis

Excess Intake of Water:

 • Primary polydipsia (a.k.a. "psychogenic polydipsia")

 • Large volume IVF

Excess Tubular Solute (a.k.a. osmotic diuresis): 

 • Excess Na+: Conventional diuretics

 • Excess glucose: Poorly controlled diabetes mellitus, SGLT2 inhibitors (e.g. gliflozins)

 • Other: Mannitol

Defect in Tubular Reabsorption of Water (a.k.a. Diabetes Insipidus):

 • Central Dl (Low production Of ADH): Idiopathic, Post-neurosurgery, Trauma, Infiltrative diseases, Hypoxic injury, Tumor

 • Nephrogenic DI (Renal resistance to ADH): Hereditary, Lithium, Hypercalcemia

Polyuria Mimics (↑ urine frequency without ↑ urine volume):

 • UTI, BPH, Detrusor overactivity (a.k.a. "overactive bladder")



- Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedicalLectures/



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