Magnesium Absorption and Pathophysiology 

Magnesium Absorption: 

 • absorbed in the GIT — small intestine, Saturable active transcellular transport, Non-saturable passive paracellular transport

Storage & Distribution

 • 99% in storage form in bone, skeletal and soft tissue, 1% in serum and red blood cell

Excretion

 • 80% of absorbed magnesium is filtered

 • 90-95 % of filtered magnesium is reabsorbed

 • 3-5% excreted in urine

 • 15-20% is reabsorbed in PCT

 • 60-75% in thick ascending limb of loop of Henle

 • 5-10% in DCT



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