Systemic Lupus Erythematosus - Diagnosis

Manifestations:

 - Arthritis 69%

 - Malar rash 40%

 - Fever 36%

 - Photosensitivity 29%

 - Raynaud's 18%

 - Serositis 17%

 - Nephropathy 16%

 - Oral ulcers 11%

 - Neurological 12%

 - Thrombocytopenia 9%

 - Lymphadenopathies 7%

 - Hemolytic anemia 4%

 - Myositis 4%

 - Lung involvement 3%

SLE-Related Auto-Antibodies:

 - ANA 95-100%

 - Anti-dsDNA 60-80%

 - Anti-nucleosome 60-70%

 - Anti-histone 60-70%

 - Anti-SSA 30-40%

 - Anti-SSB 5-10%

 - Anti-(U1)RNP 15-30%

 - Anti-Sm 10-30%

 - Anti-RiboP 5-15%

 - Anti-Ku 5-10%

 - Anti-PCNA 1-5%

 - Anti-cardiolipin (aPL) 30-70%

 - Anti-B2GP1 (aPL) 30-45%

Differential Diagnosis and Lupus Mimickers: Drug-induced lupus, Cutaneous mimickers, Other auto-immune, Infectious diseases, Hematological malignancies, Multiple sclerosis, Still's disease



Dr. Laurent ARNAUD @Lupusreference



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