Management of Lupus Nephritis

Lupus nephritis (LN) in 10 to 40% of SLE

Hallmark = proteinuria 20.5 g/g or 0.5 g/day → renal histological evaluation to determine LN severity (ISN/RPS classification) and the need for specific therapy

Goal: proteinuria <0.5-0.7 g/g by 12 months

Classification: 

 • Class I - Minimal mesangial LN

 • Class II - Mesangial proliferative LN

 • Class Ill - Focal LN (<50% of glomeruli)

    III (A) : active

    Ill (NC) : active and chronic lesions

    Ill (C) : chronic lesions

 • Class IV - Diffuse LN (>50% of glomeruli)

    Diffuse segmental (IV-S) or global

    (IV-G) LN

    IV (A) : active lesions

    IV (A/C) : active and chronic lesions

    IV (C) : chronic lesions

 • Class V - Membranous LN

 • Class VI - Advanced sclerosing LN



By  Dr. Chloé Baillou @BaillouChloe



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