Indications for tPA in Stroke:

 • Clinical diagnosis of ischemic stroke

 • Measurable neurologic deficit

 • Onset of symptoms < 4.5 hours prior to intravenous tPA administration (unless age >80 or other less common features are present, in which case onset must be < 3 hours)

Absolute Contraindications to tPA (incomplete list):

 • Ischemic stroke, head trauma, or neurosurgery (intracranial or intraspinal) within previous 3 months

 • Previous intracranial hemorrhage

 • Active internal bleeding

 • Intracranial neoplasm, AVM, or aneurysm

 • SBP > 185mmHg or DBP > 110mmHg

 • Platelet count < 100,000/mm3

 • Therapeutic anticoagulation

 • Arterial puncture at noncompressible site within the past 7 days



- Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedicalLectures/



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