Hepatobiliary Manifestations of Sickle Cell Disease

Acute sickle cell hepatic crisis:

 • Fever, acute onset RUQ pain, jaundice and tender hepatomegaly

 • Supportive with treatment of SCD crisis

Acute Hepatic sequestration:

 • Acute onset RUQ pain, hepatomegaly and anemia

 • Supportive with blood or exchange transfusion

Acute intrahepatic cholestasis:

 • Fever, RUQ pain rapidly progressing to acute liver failure

 • Supportive, exchange transfusion, correction of coagulopathy? Liver transplant



BWH Medicine Chiefs @BrighamChiefs



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