Sickle Cell Disease (SCD) Nephropathy

 • Cortical Manifestations

    - Main issue: Hemolysis-associated endothelial dysfunction

 • Early alterations

 • Late alterations

    - Proteinuria

    - Glomerular pathology

    - CKD/ESKD

 • Medullary Manifestations

    - Hematuria

    - Papillary Necrosis

 • Tubular Manifestations

    - Supranormal proximal tubular

    - Impaired concentrating ability with resultant isosthenuria

    - Impaired K secretion

    - Incomplete RTA



- Nasim Wiegley, MD @NWiegley



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