Causes of Severe Aortic Regurgitation - Differential Diagnosis

Acute:

 • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute Prosthetic Valve Dysfunction, Post Acute Balloon Valvuoplasty

 • Aorta: Acute Aortic Dissection, Traumatic Injury to Root

Chronic - Leaflet:

 • Infection: Infective Endocarditis, Rheumatic Fever, Whipple Disease

 • Inflammatory: Lupus, Rheumatoid Arthritis, Ankylosing Spondylitis, Takayasu Arteritis, Crohn Disease

 • Structural: Calcific AoV, Bicuspid AoV, Unicuspid or Quadricuspid AoV, Congenital Aortic Regurgitation, Myxomatous Degeneration, Prosthetic Valve Dysfunction

Chronic - Aorta:

 • Infxn + Inflammatory: Infectious Aortitis (i.e., Syphilis, Salmonella), Giant Cell Arteritis, Takayasu Arteritis, Behcet Syndrome, Relapsing Polychondritis, Reactive Arthritis, Psoriatic Arthritis, IgG4 Disease, Cogan's Disease

 • Genetic Aortopathy: Osteogenesis Imperfecta, Ehlers-Danlos Syndrome, Marfan's Loeys-Dietz, Sporadic Thoracic Aortic Aneurysms and Dissection

 • Degenerative: Systemic Arterial Hypertension, Age-Related Aortic Dilation



- Cardionerds - Karan Desai MD, MPH @karanpdesai



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