McDonald Criteria for Diagnosis of Multiple Sclerosis

 • 2 or more attacks, 2 or more lesions - None. Clinical evidence alone will suffice

 • 2 or more attacks, 1 lesion - Dissemination in space on MR (or await further clinical attack implicating a different CNS site)

 • 1 attack, 2 lesions - Dissemination in time on MR (or await further clinical attack implicating a different CNS site)

 • 1 attack, 1 lesion - Dissemination in space and time (or await further clinical attack implicating a different CNS site)

 • 0 attack progression from onset - One year of disease progression (retrospective or prospective) AND at least 2 out of 3 criteria:

    - Dissemination in space in the brain

    - Dissemination in space in the spinal cord based on 2 or more T2 lesions

    - Positive CSF



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