Lyme Disease: Early and Late Clinical manifestations

Stage 1. Localized

 • EM appears 7-14 days at the site of Ixodes bite

 • Fatigue, myalgia, arthralgia, headache, fever (not common)

 • Laboratory abnormalities are rare and mild

Stage 2. Disseminated

 • Several days-weeks after EM

 • Heralded by neurologic SSX (lymphocytic meningitis, CN palsies, radiculopathy, PN)

 • Cardiac SSX (AV block)

 • Months to several years after

 • Arthritis

    - Large joints (knees), 1-2 joints

    - Remitting, chronic

 • Neurologic

    - Cognitive impairment

    - Normal CSF

    - CSF + Lyme antibodies



WuidQ: Washington University ID Questions @WuidQ



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