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Because of its great propensity for abuse, oxycodone has come to be associated with the opioid crisis in the United States. Even when taken as prescribed, the drug—which is listed as a Schedule II prohibited substance—can cause dependency, tolerance, and addiction. Oxycodone is a prescription that is primarily targeted for drug abuse prevention efforts. Patients who are prescribed this medication are encouraged to carefully observe dosing instructions and avoid misuse, as long-term usage can lead to substantial mental and physical dependence.