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Methadone is a long-acting opioid medication with specific medical uses in pain management and opioid use disorder treatment. It works primarily by interacting with opioid receptors in the nervous system, helping reduce pain and, in appropriate treatment settings, preventing withdrawal symptoms and reducing opioid cravings. Because methadone remains active in the body for a long time, its effects can accumulate with repeated dosing. Possible effects include drowsiness, nausea, constipation, dizziness, and slowed breathing. Methadone can also interact with numerous medicines and substances. Appropriate medical supervision is important, particularly when starting treatment, changing doses, or combining it with other medications.


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