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Methadone is a long-acting opioid medicine that has important medical applications, including managing certain forms of pain and supporting treatment for opioid dependence. It works primarily by activating opioid receptors in the nervous system, which can reduce pain and help control withdrawal symptoms and cravings. Methadone stays in the body for an extended period, so its effects and buildup can require careful monitoring. Possible side effects include nausea, constipation, sweating, dizziness, tiredness, and drowsiness. More serious problems, including slowed breathing and changes in heart rhythm, can occur in some circumstances. Mixing methadone with alcohol, sedatives, or other substances that affect the nervous system may increase risks. Safe use requires following healthcare guidance, monitoring for adverse effects, and avoiding unsafe combinations.

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